The “Guardian Angel and Evil” Characters of the Big Liver Cells

One in every 4 persons in the world is overweight and develops fatty liver disease, a key risk factor for liver cancer. Importantly, fatty liver disease is usually accompanied with an increased number of polyploid liver cells, a term used to describe cells with 4 or more sets of chromosomes (set of complete genetic information).
In recently published results from a study conducted using a mouse model of fatty liver disease created through knocking out the Pten gene,  Sokoine University of Agriculture researcher, Dr. Augustine B. Matondo in collaboration with other researchers successfully inhibited the formation of polyploid cells and discovered that polyploid cells promotes lipid accumulation and prevent the development of liver cancer.
The results means: Inhibiting the development of polyploid liver cells (hepatocytes) prevents fatty liver disease but promotes development of liver cancer.

Read the full paper at this link = >


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